Pediatric Progressive Leukoencephalopathies

  • Definition: Pediatric progressive leukoencephalopathies are characterized by ongoing degeneration of the brain’s white matter, causing neurological decline.
  • They include genetic, infectious, metabolic, inflammatory, vascular, neoplastic, toxic, and iatrogenic causes.
  • Classification is informed by etiology, modern molecular approaches, neuroimaging patterns, age of onset, and clinical relevance.
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