Myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) is a distinct acquired central nervous system (CNS) demyelinating disorder, separate from multiple sclerosis (MS) and aquaporin-4 (AQP4)-seropositive neuromyelitis optica spectrum disorder (NMOSD). The presence of MOG-IgG, detected by cell-based assays, is central to diagnosis. MOGAD can present as monophasic or relapsing, with variable clinical features and outcomes.