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Reported reference values for CSF total protein (g/L) in infants, children, and adults.          
Age Mean ± SD[1](range) Range[2] Mean (range)[3]    
Term newborn   0.40–1.20   0.63 (0.32–2.40) 0.901)(0.20–1.70)
0–1 week 0.77 ± 0.16 (0.45–1.09)   0.47 (0.27–0.65)    
1–2 weeks       0.672)(0.52–1.20)  
2–3 weeks 0.66 ± 0.163) (0.51–1.01) 0.20–0.80(4)      
3–4 weeks       0.525) (0.26–0.88)  
1–2 months       0.48 (0.17–0.63)  
2–3 months 0.45 +/- 0.136) (0.24–0.65)        
3–6 months 0.29 ± 0.04 (0.23–0.37) 0.15–0.457)      
6–12 months 0.27 ± 0.07 (0.17–0.35)        
1–16 years 0.22 ± 0.05 (0.16–0.31)        
           

References

1 Age range, newborn to 1week
2 Age range, 0 to 2 weeks
3 Age range, 1 to 4 weeks
4 Age range: 0 to 4 weeks
5 Age range, 2 to 4 weeks
6 Age range, 1 to 3 months
7 Age range, 1 month to adult
1.Statz A, Felgenhauer K. Development of the blood-CSF barrier. Dev Med Child Neurol. 1983 Apr;25(2):152-61. doi: 10.1111/j.1469-8749.1983.tb13738.x.
[PMID: 6189754] [DOI: 10.1111/j.1469-8749.1983.tb13738.x]
2.Soldin JS, Brugnara C, KC Gunter, JM. Hicks, eds. Pediatric reference ranges, 2nd ed. Washington: AACC Press, 1997:181pp
3.Klein JO, Marcy SM. Bacterial sepsis and meningitis. In: Remington JS, Klein JO, eds. Infectious diseases of the fetus and newborn infant, 4th ed. Philadelphia: WB Saunders, 1995:835– 90.

Cite this: CNKE contributors.CSF Total Protein Reference Values. CNKE.org, The Child Neurology Knowledge Environment. 26 July 2025. Available at: https://cnke.org/articles/86 Accessed  26 July 2025.