Twin Pregnancies and Fetal Brain Injury

  • Twin pregnancies are associated with increased risk of mortality and neurological morbidity, especially in monochorionic twins who share a single placenta.
  • Potential mechanisms of fetal brain injury in monochorionic twins include:
    • Hypoxemia
    • Ischaemia
    • Cardiac failure
    • Anemia-polycythemia
    • Embolic complications (in survivors of co-twin demise)
    • Vaso-occlusive injury
    • Inflammatory injury
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