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Definition: Whole Genome Sequencing (WGS) is a comprehensive method for analyzing the entire DNA sequence of an organism’s genome at a single time.
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Process:
- Sample Collection: DNA is extracted from a sample (e.g., blood, saliva, tissue).
- DNA Fragmentation: The DNA is broken into smaller fragments.
- Sequencing: Each fragment is sequenced using high-throughput sequencing technologies.
- Data Assembly: Sequenced fragments are assembled to reconstruct the original genome.
- Annotation: Functional elements of the genome, such as genes and regulatory regions, are identified.
Technologies:
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