Disruption at any of the stages in metabolism could contribute to primary and/or secondary contributions to ASD

Possible Role for Metabolism in the Pathogenesis of ASD

  • Overview of Metabolism:

    • Metabolism encompasses biochemical processes for:
      • Converting food into energy to power cells
      • Synthesizing cellular components
      • Eliminating waste (López-Otín et al., 2016)

      Role of Metabolism in Altered Cognition in ASD

      • Disruption at any stage could contribute to ASD through primary and/or secondary pathways (Cheng et al., 2017; Frye, 2015; Schiff et al., 2011).
      • Metabolic disturbances at the cellular level, particularly in neuronal pathways, may cause synaptic dysfunction underlying altered cognitive development in ASD.

      Secondary Contributions of Metabolism to ASD

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