Myotonic dystrophy (DM) is the most common form of myotonic myopathy, with an estimated prevalence of 1 in 7,000 people, though milder cases often go undiagnosed.
Overview
This multisystem disorder is inherited as an autosomal dominant trait and can affect various systems, including:
- Skeletal and smooth muscle
- Eyes
- Heart
- Endocrine system
- Central nervous system
The clinical spectrum ranges from mild to very severe, categorized into three overlapping phenotypes:
- Mild
- Classic
- Congenital
