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Monday, 06 January 2025

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Editor

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Assuming effects is required, the following 69 results were found.

  1. NGN-401https://cnke.org/articles/160

    dendritic spine morphology and synaptic density. Safety Profile: Dose-escalation studies confirmed minimal off-target effects and no evidence of systemic toxicity. Clinical Trials Initial Phase I/II clinical trials have focused on safety, tolerability,...

    • Type: Article
    • Author: Editor
    • Category: Home

  2. Developmental Dysarthria in Syndromic Conditionshttps://cnke.org/articles/245

    Developmental Dysarthria in Syndromic Conditions Causes: Often linked to structural brain anomalies such as perisylvian or perirolandic polymicrogyria, cerebellar anomalies, Joubert syndrome, and brainstem dysgenesis. Differential Diagnosis: Childhood...

    • Type: Article
    • Author: Editor CNKE
    • Category: Articles

  3. Idiopathic Intracranial Hypertensionhttps://cnke.org/articles/178

    function (per IIHTT study). Topiramate: Dual role: Anti-migraine and appetite suppression. Caution for cognitive side effects and depression. Headache Management: Migrainous phenotype: Use migraine preventives that do not promote weight gain. Address...

    • Type: Article
    • Author: Editor
    • Category: Home

  4. Pyridoxal 5 Phosphate Dependent Epilepsyhttps://cnke.org/articles/31

    PNPO deficiency (OMIM 6032870) is an autosomal recessive inborn error of metabolism that leads to a seizure disorder, presenting in the newborn period (neonatal epileptic encephalopathy) or early infancy, that can be treated with pyridoxal 5’-phosphate...

    • Type: Article
    • Author: Editor CNKE
    • Category: Articles

  5. Ataxias: Differential Diagnosishttps://cnke.org/articles/185

    tumors to the cerebellum Abscess: Infectious collections in the cerebellum causing localized inflammation and pressure effects. Systemic Causes Liver Failure: Hepatocerebral Degeneration: Resulting from chronic liver dysfunction leading to toxic effects...

    • Type: Article
    • Author: Editor
    • Category: Home

  6. Genetic Epilepsy with Febrile Seizures Plus (GEFS+)https://cnke.org/articles/276

    of GABAA receptor ion channels GABAA receptor channels inhibit signaling between neurons Involved in nerve signaling Effects of SCN1A Gene Mutations Variety of Effects on Sodium Channels Many mutations causing Dravet syndrome: reduce the number of...

    • Type: Article
    • Author: Editor
    • Category: Home

  7. ADCY5 Dyskinesiahttps://cnke.org/articles/213

    quality, and fine motor skills. Safety Profile: Well-Tolerated; Safe for use, even in pediatric populations. Reported Side Effects:Hyperactivity in some patients. Dosage Example Regimen:Moderately strong cappuccino three times a day. Third dose no...

    • Type: Article
    • Author: Editor CNKE
    • Category: Articles

  8. How to edit this Knowledge Basehttps://cnke.org/about/182

    Tha aim of CNKE.org is to develop a comprehensive continually updated trustworthy resource in child neurology. This can only be made possible through collaborative content authoring. There are several ways you can get involved in creating and...

    • Type: Article
    • Author: Editor
    • Category: About

  9. Why a Lecture Notes Style Knowledgebase on Child Neurology?https://cnke.org/about/180

    The CNKE favours a lecture notes style approach for its articles for Clarity and Readability Inline citations can disrupt the flow of reading, especially for topics that require a step-by-step understanding of complex concepts. A lecture notes-style...

    • Type: Article
    • Author: Editor
    • Category: About

  10. The Normal EEG in Childrenhttps://cnke.org/articles/25

    commonly seen using bipolar anteroposterior or coronal montages. Such apparent asymmetries may be due to field cancellation effects and should be verified using an ipsilateral ear reference run. However, even then, shifting asymmetries may normally be...

    • Type: Article
    • Author: Editor CNKE
    • Category: Articles

  11. PRRT2-Associated Disordershttps://cnke.org/articles/274

    Short-term potentiation (STP) phenomena in response to short-duration, increasing frequency stimulation show opposite effects on excitatory (glutamatergic) and inhibitory (GABAergic) synapses. Increased facilitation in excitatory transmission and...

    • Type: Article
    • Author: Editor
    • Category: Home

  12. Paroxysmal Kinesigenic Dyskinesiashttps://cnke.org/articles/271

    Historical Background The first known description of paroxysmal kinesigenic dyskinesias (PKD) was by Shuzo Kure (1892) detailing a Japanese man with PKD. Initial reports often regarded PKD as a form of reflex epilepsy. Currently it considered as one of...

    • Type: Article
    • Author: Editor
    • Category: Home

  13. Epilepsy in Rett Syndromehttps://cnke.org/articles/156

    Introduction Prevalence: Epilepsy affects 50–70% of individuals with RTT, though earlier studies suggested rates as high as 90%. Variability in study designs and diagnostic criteria contribute to these differences. Epileptic and Nonepileptic Events:...

    • Type: Article
    • Author: Editor
    • Category: Home

  14. Sleep issues in Rett Syndromehttps://cnke.org/articles/158

    Key points: Prevalence and Onset: Sleep problems affect 70–80% of individuals with RTT, with onset becoming evident between 18 months and 2 years. Sleep disturbances in RTT are significantly more common than in typically developing children. Sleep...

    • Type: Article
    • Author: Editor
    • Category: Home

  15. Narcolepsy-Cataplexyhttps://cnke.org/articles/241

    for excessive daytime sleepiness, methylphenidate, and amphetamines, which may help some patients but have transitory effects. Antidepressants, such as selective serotonin reuptake inhibitors (SSRIs) or imipramine, can benefit cataplexy, and sodium...

    • Type: Article
    • Author: Editor
    • Category: Home

  16. Familial (Autosomal Dominant) Focal Epilepsieshttps://cnke.org/articles/357

    an EEG spike focus, indicating it as a marker for the syndrome. Prognosis: Development is usually normal. Management: Effects of new AEDs not directly evaluated. Carbamazepine and phenytoin appear to be effective. Autosomal Dominant Rolandic Epilepsy...

    • Type: Article
    • Author: Editor
    • Category: Home

  17. Rett Syndrome : Therapy prospectshttps://cnke.org/articles/159

    due to challenges in design and heterogeneity in participants. Ongoing Trials: IGF-1 (Mecasermin): Positive neurobehavioral effects like reduced anxiety and apnea. Sarizotan: Focuses on improving respiratory irregularities. Trofinetide: Synthetic IGF-1...

    • Type: Article
    • Author: Editor
    • Category: Home

  18. Ion channel disordershttps://cnke.org/articles/231

    Ion channel disorders, or channelopathies, are a group of conditions that involve dysfunctions in ion channels—integral membrane proteins regulating the flow of ions across cellular membranes. In skeletal muscle, these disorders variably produce...

    • Type: Article
    • Author: Editor CNKE
    • Category: Articles

  19. Trofinetidehttps://cnke.org/articles/161

    common genetic cause of intellectual disability. Traumatic Brain Injury (TBI): Its neuroprotective and anti-inflammatory effects hold promise in reducing secondary injury cascades post-TBI. Clinical Trials and Efficacy Recent Phase III clinical trials...

    • Type: Article
    • Author: Editor
    • Category: Home

  20. Guillaume Duchenne (1806–1875)https://cnke.org/historical-vignettes/175

    palsy impacting newborns. Duchenne's Disease (Tabes Dorsalis): His work contributed to understanding the neurodegenerative effects of syphilis on the spinal cord. Duchenne's Paralysis (Progressive Bulbar Palsy): His clinical observations helped...

    • Type: Article
    • Author: Biju Hameed
    • Category: Historical Vignettes
Results 21 - 40 of 69