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Saturday, 12 April 2025

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Assuming effects is required, the following 72 results were found.

  1. Helmet therapy for cranial deformitieshttps://cnke.org/articles/helmet-therapy-for-cranial-deformities

    benefit of helmets over repositioning techniques and physiotherapy. Helmets can be costly and resource-intensive. Adverse Effects Skin irritation or pressure sores. Discomfort or poor tolerance by the infant. Parental stress related to maintenance and...

    • Type: Article
    • Author: Editor CNKE
    • Category: Articles

  2. Levetiracetamhttps://cnke.org/articles/278

    varies based on age and weight. Typically starts at 10 mg/kg twice daily, with adjustments based on clinical response. Side Effects Common: Drowsiness, dizziness, fatigue, headache, irritability. Serious: Behavioral changes (aggression, agitation),...

    • Type: Article
    • Author: Editor CNKE
    • Category: Articles

  3. NGN-401https://cnke.org/articles/160

    dendritic spine morphology and synaptic density. Safety Profile: Dose-escalation studies confirmed minimal off-target effects and no evidence of systemic toxicity. Clinical Trials Initial Phase I/II clinical trials have focused on safety, tolerability,...

    • Type: Article
    • Author: Editor CNKE
    • Category: Articles

  4. Developmental Dysarthria in Syndromic Conditionshttps://cnke.org/articles/245

    Developmental Dysarthria in Syndromic Conditions Causes: Often linked to structural brain anomalies such as perisylvian or perirolandic polymicrogyria, cerebellar anomalies, Joubert syndrome, and brainstem dysgenesis. Differential Diagnosis: Childhood...

    • Type: Article
    • Author: Editor CNKE
    • Category: Articles

  5. Idiopathic Intracranial Hypertensionhttps://cnke.org/articles/178

    function (per IIHTT study). Topiramate: Dual role: Anti-migraine and appetite suppression. Caution for cognitive side effects and depression. Headache Management: Migrainous phenotype: Use migraine preventives that do not promote weight gain. Address...

    • Type: Article
    • Author: Editor CNKE
    • Category: Articles

  6. Pyridoxal 5 Phosphate Dependent Epilepsyhttps://cnke.org/articles/31

    PNPO deficiency (OMIM 6032870) is an autosomal recessive inborn error of metabolism that leads to a seizure disorder, presenting in the newborn period (neonatal epileptic encephalopathy) or early infancy, that can be treated with pyridoxal 5’-phosphate...

    • Type: Article
    • Author: Editor CNKE
    • Category: Articles

  7. Ataxias: Differential Diagnosishttps://cnke.org/articles/185

    tumors to the cerebellum Abscess: Infectious collections in the cerebellum causing localized inflammation and pressure effects. Systemic Causes Liver Failure: Hepatocerebral Degeneration: Resulting from chronic liver dysfunction leading to toxic effects...

    • Type: Article
    • Author: Editor CNKE
    • Category: Articles

  8. ADCY5 Dyskinesiahttps://cnke.org/articles/213

    quality, and fine motor skills. Safety Profile: Well-Tolerated; Safe for use, even in pediatric populations. Reported Side Effects:Hyperactivity in some patients. Dosage Example Regimen:Moderately strong cappuccino three times a day. Third dose no...

    • Type: Article
    • Author: Editor CNKE
    • Category: Articles

  9. Genetic Epilepsy with Febrile Seizures Plus (GEFS+)https://cnke.org/articles/276

    of GABAA receptor ion channels GABAA receptor channels inhibit signaling between neurons Involved in nerve signaling Effects of SCN1A Gene Mutations Variety of Effects on Sodium Channels Many mutations causing Dravet syndrome: reduce the number of...

    • Type: Article
    • Author: Editor CNKE
    • Category: Articles

  10. Why a Lecture Notes Style Knowledgebase on Child Neurology?https://cnke.org/about/180

    The CNKE favours a lecture notes style approach for its articles for Clarity and Readability Inline citations can disrupt the flow of reading, especially for topics that require a step-by-step understanding of complex concepts. A lecture notes-style...

    • Type: Article
    • Author: Editor CNKE
    • Category: About

  11. How to edit this Knowledge Basehttps://cnke.org/about/182

    Tha aim of CNKE.org is to develop a comprehensive continually updated trustworthy resource in child neurology. This can only be made possible through collaborative content authoring. There are several ways you can get involved in creating and...

    • Type: Article
    • Author: Editor CNKE
    • Category: About

  12. The Normal EEG in Childrenhttps://cnke.org/articles/25

    commonly seen using bipolar anteroposterior or coronal montages. Such apparent asymmetries may be due to field cancellation effects and should be verified using an ipsilateral ear reference run. However, even then, shifting asymmetries may normally be...

    • Type: Article
    • Author: Editor CNKE
    • Category: Articles

  13. PRRT2-Associated Disordershttps://cnke.org/articles/274

    Short-term potentiation (STP) phenomena in response to short-duration, increasing frequency stimulation show opposite effects on excitatory (glutamatergic) and inhibitory (GABAergic) synapses. Increased facilitation in excitatory transmission and...

    • Type: Article
    • Author: Editor CNKE
    • Category: Articles

  14. Sleep issues in Rett Syndromehttps://cnke.org/articles/158

    Key points: Prevalence and Onset: Sleep problems affect 70–80% of individuals with RTT, with onset becoming evident between 18 months and 2 years. Sleep disturbances in RTT are significantly more common than in typically developing children. Sleep...

    • Type: Article
    • Author: Editor CNKE
    • Category: Articles

  15. Epilepsy in Rett Syndromehttps://cnke.org/articles/156

    Introduction Prevalence: Epilepsy affects 50–70% of individuals with RTT, though earlier studies suggested rates as high as 90%. Variability in study designs and diagnostic criteria contribute to these differences. Epileptic and Nonepileptic Events:...

    • Type: Article
    • Author: Editor CNKE
    • Category: Articles

  16. Paroxysmal Kinesigenic Dyskinesiashttps://cnke.org/articles/271

    Historical Background The first known description of paroxysmal kinesigenic dyskinesias (PKD) was by Shuzo Kure (1892) detailing a Japanese man with PKD. Initial reports often regarded PKD as a form of reflex epilepsy. Currently it considered as one of...

    • Type: Article
    • Author: Editor CNKE
    • Category: Articles

  17. Rett Syndrome : Therapy prospectshttps://cnke.org/articles/159

    due to challenges in design and heterogeneity in participants. Ongoing Trials: IGF-1 (Mecasermin): Positive neurobehavioral effects like reduced anxiety and apnea. Sarizotan: Focuses on improving respiratory irregularities. Trofinetide: Synthetic IGF-1...

    • Type: Article
    • Author: Editor CNKE
    • Category: Articles

  18. Narcolepsy-Cataplexyhttps://cnke.org/articles/241

    for excessive daytime sleepiness, methylphenidate, and amphetamines, which may help some patients but have transitory effects. Antidepressants, such as selective serotonin reuptake inhibitors (SSRIs) or imipramine, can benefit cataplexy, and sodium...

    • Type: Article
    • Author: Editor CNKE
    • Category: Articles

  19. Familial (Autosomal Dominant) Focal Epilepsieshttps://cnke.org/articles/357

    an EEG spike focus, indicating it as a marker for the syndrome. Prognosis: Development is usually normal. Management: Effects of new AEDs not directly evaluated. Carbamazepine and phenytoin appear to be effective. Autosomal Dominant Rolandic Epilepsy...

    • Type: Article
    • Author: Editor CNKE
    • Category: Articles

  20. Ion channel disordershttps://cnke.org/articles/231

    Ion channel disorders, or channelopathies, are a group of conditions that involve dysfunctions in ion channels—integral membrane proteins regulating the flow of ions across cellular membranes. In skeletal muscle, these disorders variably produce...

    • Type: Article
    • Author: Editor CNKE
    • Category: Articles
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