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developmental is required, and dysarthria is required

Alexander Disease

Type: Article Author: Editor CNKE Category: Articles Language: * Editor:
Editor(s)
Alexander disease is a rare neurodegenerative disorder caused by mutations in the glial fibrillary acidic protein, a type III intermediate filament protein expressed in astrocytes. Introduction Definition: Alexander disease is a progressive disorder of...
07 January 2025
https://cnke.org/articles/253

Acquired Dysarthria

Type: Article Author: Editor CNKE Category: Articles Language: *
Dysarthria is a speech articulation impairment affecting intelligibility, particularly through consonant production. It can also disrupt phonation, resonation, and prosody, leading to slurred, effortful speech. Dysarthria is often associated with...
04 January 2025
https://cnke.org/articles/247

Speech and Language developmental disorders

Type: Article Author: Editor CNKE Category: Articles Language: *
Definition and Components of Language and Speech Language: A communication system acquired through use, involving symbols sequenced to share attention and ideas. Speech: One mechanism for expressing language, but other methods like gestures, sign...
04 January 2025
https://cnke.org/articles/243

Developmental Dysarthria in Syndromic Conditions

Type: Article Author: Editor CNKE Category: Articles Language: * Editor:
Editor(s)
Developmental Dysarthria in Syndromic Conditions Causes: Often linked to structural brain anomalies such as perisylvian or perirolandic polymicrogyria, cerebellar anomalies, Joubert syndrome, and brainstem dysgenesis. Differential Diagnosis: Childhood...
04 January 2025
https://cnke.org/articles/245

Developmental Dysarthria

Type: Tag Author: Editor CNKE Language: *
https://cnke.org/topics/developmental-dysarthria

Cerebellar ataxias according to main clinical features

Type: Article Author: Editor CNKE Category: Articles Language: * Editor:
Editor(s)
&
Editor(s)
Diseases Associated with Chorea Ataxia-Telangiectasia and Related Conditions ATX–ATM (Ataxia-Telangiectasia Mutated gene) A progressive condition involving cerebellar ataxia, oculomotor apraxia, immunodeficiency, and increased risk of malignancies....
29 December 2024
https://cnke.org/articles/183

CNS Degenerative Disorders in Infancy

Type: Article Author: Editor CNKE Category: Articles Language: * Editor:
Editor(s)
Disease Enzyme Defect and Genetics Onset Early Manifestations Vision and Hearing Somatic Findings Motor Findings Seizures Labs Clinical Course White matter Globoid (Krabbe) leukodystrophy Recessive galactocerebroside β-galactosidase deficiency....
08 June 2024
https://cnke.org/articles/314

ADCY5 Dyskinesia

Type: Article Author: Editor CNKE Category: Articles Language: * Editor:
Editor(s)
ADCY5 dyskinesia is a hyperkinetic movement disorder characterized by infantile to late-adolescent onset of chorea, athetosis, dystonia, myoclonus, or a combination of these. Overview Hyperkinetic movement disorder, more prominent in the face and arms...
03 January 2025
https://cnke.org/articles/213

Dysarthria: Clinical features

Type: Article Author: Editor CNKE Category: Articles Language: * Editor:
Editor(s)
Flaccid Dysarthria (Lower Motor Neuron Lesion) Clinical Features: Lax open mouth Atonia Weakness Wasting Drooling Feeding difficulties Absent jaw, gag, and cough reflexes Causes: Dystrophia myotonica Prader-Willi Syndrome Myasthenia gravis...
02 January 2025
https://cnke.org/articles/205

Significant historical advances, theories, and practices surrounding cerebral palsy from ancient times through the mid-20th century

Type: Article Author: Editor CNKE Category: Historical Vignettes Language: *
Significant historical advances, theories, and practices surrounding cerebral palsy from ancient times through the mid-20th century. Historical Timeline 1196–1190 BCE: Pharaoh Siptah exhibits earliest recorded CP-like symptoms. 1580–1350 BCE: Stele of...
29 April 2025
https://cnke.org/historical-vignettes/significant-historical-advances-theories-and-practices-surrounding-cerebral-palsy-from-ancient-times-through-the-mid-20th-century

Repeat Expansions

Type: Article Author: Editor CNKE Category: Articles Language: * Editor:
Editor(s)
Introduction to Repeat Expansions Definition: Repeat expansions refer to the abnormal increase in the number of tandem nucleotide repeats in specific regions of the genome. Examples: CAG, CGG, CTG, GAA repeats. Significance: These expansions can...
29 December 2024
https://cnke.org/articles/187

Polymicrogyria

Type: Article Author: Editor CNKE Category: Articles Language: *
Polymicrogyria Definition: Polymicrogyria (PMG) is a malformation of cortical development that arises during the late phase of neuronal migration and into the early phase of cortical organization. Gross Morphology: The cortex has many excessively small...
01 May 2025
https://cnke.org/articles/polymicrogyria

Familial (Autosomal Dominant) Focal Epilepsies

Type: Article Author: Editor CNKE Category: Articles Language: * Editor:
Editor(s)
Overview: Temporal lobe epilepsy was traditionally considered an acquired condition. Causes include lesions such as: Hippocampal sclerosis Tumours Trauma Vascular malformations Malformations of cortical development Recent research has highlighted the...
20 June 2024
https://cnke.org/articles/357

Inherited Cerebellar Ataxias (ICAs)

Type: Article Author: Editor CNKE Category: Articles Language: *
ICAs are a group of rare, complex neurodegenerative diseases primarily affecting the cerebellum Introduction and Overview Definition: ICAs are a group of rare, complex neurodegenerative diseases primarily affecting the cerebellum Additional...
29 December 2024
https://cnke.org/articles/184

Pompe Disease

Type: Article Author: Editor CNKE Category: Articles Language: * Editor:
Editor(s)
Overview Definition: Pompe disease is a lysosomal storage disorder caused by defective glycogenolysis, leading to glycogen accumulation in lysosomes. Pathophysiology: Lysosome rupture leads to tissue damage. Primarily affects skeletal and cardiac...
10 December 2024
https://cnke.org/articles/470

CNS Degenerative Disorders of Childhood

Type: Article Author: Editor CNKE Category: Articles Language: * Editor:
Editor(s)
Disease Enzyme Defect and Genetics Onset Early Manifestations Vision and Hearing Motor System Seizures Laboratory and Tissue Studies Course Adrenoleukodystrophy and variants (peroxisomal disease) X-linked Xq28 Neonatal form: AR Acyl-CoA synthetase 5–10...
08 June 2024
https://cnke.org/articles/315

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