Cellular Mechanisms of Intrapartum Hypoxic–Ischaemic Cerebral Injury
- The immature brain has a lower overall oxygen demand compared to the mature brain; however, regions undergoing active maturation have significantly higher oxygen needs.
- High oxygen demands in actively maturing regions are critical for enzyme functions involved in neuronal development, ion homeostasis (e.g., Na K-ATPase), and oxidative metabolism.
- Failure to meet regional energy demands during fetal asphyxia leads to rapid energy depletion, initiating cellular injury and cell death cascades.
Role of Glutamate in Brain Development and Injury
Login to Read More
