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Last updated: 07 June 2024

AED Choice in Epilepsy

Information
Anti-epileptic drugs
Choice Antiepileptic Drug (AED)medication in children      
Seizure type/syndrome First Line Second Line Drugs to avoid
Focal seizures CBZ,LTG,OXC,TPM,VPA CLB,GBP,LEV,PHT,TGB,ZON,PGN  
Generalised Seizures      
Absence ESM,LTG,VPA CLB,CLM,TPM CBZ,GBP,OXC,TGB,VGB
GTC CBZ,LTG,VPA,TPM CLB,LEV,OXC,ZON TGB,VGB
Myoclonic VPA,TPM LTG,CLB,CLM,LEV,Piracetam CBZ,GBP,OXC,TGB,VGB
Tonic LTG,VPA CLB,CLM,LEV,TPM CBZ,OXC
Atonic LTG,VPA LEV,TPM,CLB,CLM CBZ,OXC,PHT
Childhood absence epilepsy ESM,LTG,VPA LEV,TOP CBZ,OXC,PHT,TGB,VGB
Juvenile absence epilepsy LTG,VPA LEV,TPM CBZ,OXC,PHT,TGB,VGB
Juvenile myoclonic epilepsy LTG,VPA CLB,CLM,TPM,LEV CBZ,OXC,PHT,TGB,VGB
BECTS CBZ,LTG,OXC,VPA LEV,TPM  
BCOS CBZ,LTG,OXC,VPA LEV,TPM  
Infantile spasms VGB,Steroids CLB,CLM,VPA,TPM CBZ,OXC
Dravets VPA,TPM,CLB,CLM LEV,Stiripentol CBZ,LTG,OXC,VGB
Lennox-Gastuat Syndrome VPA,LTG,TPM CLB,CLM,ESM,LEV,RUF CBZ,OXC
Landau-Kleffner syndrome Steroids,LTG,VPA LEV,TPM CBZ,OXC
CSWS Steroids,CLB,CLM,VPA,LTG,ESM LEV,TPM CBZ,OXC,VGB
Myoclonic astatic epilepsy CLB,CLM,VPA,TPM LEV,LTG CBZ,OXC

ESM Ethosuximide
CLB Clobazam
CLM Clonazepam
GBP Gabapentin
LEV Levetiracetam
LTG Lamotrigine
OXC Oxcarbazepine
PGN Pregabalin
PHT Phenytoin
RUF Rufinamide
TGB Tiagabine
TPM Topiramate
VGB Vigabatrin
VPA Valproate
ZON Zonisamide

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