Choice Antiepileptic Drug (AED)medication in children | |||
Seizure type/syndrome | First Line | Second Line | Drugs to avoid |
Focal seizures | CBZ,LTG,OXC,TPM,VPA | CLB,GBP,LEV,PHT,TGB,ZON,PGN | |
Generalised Seizures | |||
Absence | ESM,LTG,VPA | CLB,CLM,TPM | CBZ,GBP,OXC,TGB,VGB |
GTC | CBZ,LTG,VPA,TPM | CLB,LEV,OXC,ZON | TGB,VGB |
Myoclonic | VPA,TPM | LTG,CLB,CLM,LEV,Piracetam | CBZ,GBP,OXC,TGB,VGB |
Tonic | LTG,VPA | CLB,CLM,LEV,TPM | CBZ,OXC |
Atonic | LTG,VPA | LEV,TPM,CLB,CLM | CBZ,OXC,PHT |
Childhood absence epilepsy | ESM,LTG,VPA | LEV,TOP | CBZ,OXC,PHT,TGB,VGB |
Juvenile absence epilepsy | LTG,VPA | LEV,TPM | CBZ,OXC,PHT,TGB,VGB |
Juvenile myoclonic epilepsy | LTG,VPA | CLB,CLM,TPM,LEV | CBZ,OXC,PHT,TGB,VGB |
BECTS | CBZ,LTG,OXC,VPA | LEV,TPM | |
BCOS | CBZ,LTG,OXC,VPA | LEV,TPM | |
Infantile spasms | VGB,Steroids | CLB,CLM,VPA,TPM | CBZ,OXC |
Dravets | VPA,TPM,CLB,CLM | LEV,Stiripentol | CBZ,LTG,OXC,VGB |
Lennox-Gastuat Syndrome | VPA,LTG,TPM | CLB,CLM,ESM,LEV,RUF | CBZ,OXC |
Landau-Kleffner syndrome | Steroids,LTG,VPA | LEV,TPM | CBZ,OXC |
CSWS | Steroids,CLB,CLM,VPA,LTG,ESM | LEV,TPM | CBZ,OXC,VGB |
Myoclonic astatic epilepsy | CLB,CLM,VPA,TPM | LEV,LTG | CBZ,OXC |
ESM Ethosuximide
CLB Clobazam
CLM Clonazepam
GBP Gabapentin
LEV Levetiracetam
LTG Lamotrigine
OXC Oxcarbazepine
PGN Pregabalin
PHT Phenytoin
RUF Rufinamide
TGB Tiagabine
TPM Topiramate
VGB Vigabatrin
VPA Valproate
ZON Zonisamide