Overview

• Mucopolysaccharidoses (MPS) are lysosomal storage disorders due to enzyme deficiencies impairing degradation of glycosaminoglycans (GAGs), also known as mucopolysaccharides.
• GAGs are complex sugar molecules found in connective tissues, skin, cartilage, cornea, liver, spleen, and vascular tissues.
• Examples: Dermatan sulfate, heparan sulfate, keratan sulfate, chondroitin sulfate, hyaluronic acid.
• Most MPS disorders are autosomal recessive, except MPS II (Hunter syndrome), which is X-linked.To read more, a subscription is needed: Click here to subscribe