Overview
Oligoclonal bands (OCBs) are bands of immunoglobulins that are seen when a patient's blood serum, or cerebrospinal fluid (CSF) is analyzed. The presence of two or more bands of immunoglobulin on isoelectric focusing (IEF ) of CSF is referred to as 'oligoclonal bands' (OCBs). This CSF oligoclonal banding is only indicative of local CNS IgG production when the banding pattern in the CSF is distinct from the pattern seen in the serum.
While OCBs are well known to assist in the diagnosis of multiple sclerosis it is important to recognize that they are found in many other situations like infections
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subacute sclerosing panencephalitis
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- Editor(s): CNKE contributors