Trofinetide is a synthetic analogue of glycine-proline-glutamate (GPE), an amino-terminal tripeptide derived from insulin-like growth factor-1 (IGF-1). It is emerging as a promising therapeutic agent for neurodevelopmental and neurodegenerative disorders due to its unique mechanism of action that targets inflammation, oxidative stress, and synaptic dysfunction—common pathological features in many neurological conditions.
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