Trofinetide is a synthetic analogue of glycine-proline-glutamate (GPE), an amino-terminal tripeptide derived from insulin-like growth factor-1 (IGF-1). It is emerging as a promising therapeutic agent for neurodevelopmental and neurodegenerative disorders due to its unique mechanism of action that targets inflammation, oxidative stress, and synaptic dysfunction—common pathological features in many neurological conditions.
Mechanism of Action
Trofinetide’s therapeutic potential lies in its ability to modulate inflammatory pathways and support synaptic health: