Introduction
- Prevalence: Epilepsy affects 50–70% of individuals with RTT, though earlier studies suggested rates as high as 90%. Variability in study designs and diagnostic criteria contribute to these differences.
- Epileptic and Nonepileptic Events: RTT patients often experience nonepileptic paroxysmal events, which can complicate diagnosis.
- MECP2 Mutations: Epilepsy is more common in individuals without MECP2 mutations, often due to the early epileptic variant linked to CDKL5 mutations.