Disruption at any of the stages in metabolism could contribute to primary and/or secondary contributions to ASD

Possible Role for Metabolism in the Pathogenesis of ASD

• Overview of Metabolism:

  • Metabolism encompasses biochemical processes for:
    • Converting food into energy to power cells
    • Synthesizing cellular components
    • Eliminating waste (López-Otín et al., 2016)

    Role of Metabolism in Altered Cognition in ASD

    • Disruption at any stage could contribute to ASD through primary and/or secondary pathways (Cheng et al., 2017; Frye, 2015; Schiff et al., 2011).
    • Metabolic disturbances at the cellular level, particularly in neuronal pathways, may cause synaptic dysfunction underlying altered cognitive development in ASD.

    Secondary Contributions of Metabolism to ASD

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    Keywords: autism, metabolic derangements in autism, nutritional supplements in autism, omega 3 fatty acids, ketogenic diet in autism, N-acetylcysteine in autism, cerebral folate deficiency, folinic acid in autism, vitamins in autism

    Published:25 June 2024 Last Updated:29 December 2024